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HomeMy WebLinkAbout0149_001Village of--,Aount Prospe. ct- Mount Prospect, Illinois MAI#— INTEROFFICE MEMORANDUM TO: MAYOR GERALD L. FARLEY AND BOARD OF TRUSTEES FROM: VILLAGE MANAGER DATE: SEPTEMBER 6, 1989 SUBJECT: NORTBFIELD LABORATORIES, INC. In 1988, the Village was contacted by a laboratory which wished to do urine and blood testing for world class athletes including Olympic contestants. In addition, they would do other laboratory type work. I was called by a resident, north of Opus, indicating his displeasure in having a laboratory in Opus since he felt vials of AIDS infected blood had the potential to be spilled on the roadways and sidewalks while being delivered and could infect all residents living north of Opus Center. We had extensive discussions concerning the safety precautions that were being undertaken by this laboratory. Before the laboratory came forward with Building Permits, they wee bought out by a larger company and never did proceed with the location in the Opus Center. We have been approached by Northfield Laboratories, which is not connected with the group that contacted us in 1988. Northfield Laboratories has developed, in the last two decades, a technique to extend the life of red blood cells for blood transfusions. They are in the process of establishing a pilot laboratory on the Opus site before endeavoring to mass produce their finished product. Representatives will be present at the Committee meeting to explain what their process is and to indicate the extensive precautionary measures in which they have to abide. They are able to take donated blood which has already been screened by LifeSource and other blood centers that has expired and "tend the life up to one full year by extracting the red blood cellswhich also allows transfusions to take place without the need for a blood type. The Federal government and Red Cross are extremely interested in this product and have been extensively involved with funding in the past. North field Laboratories feels they are on the cutting edge of new technology in medical science which would be beneficial in disaster areas. They are anxious to move ahead with the Laboratory in Opus. They have met all the requirements of Codes and the only purpose is to explain what they will be doing and to give any residents who may have concerns the opportunity to hear what National Laboratories is intending to be doing and what precautions they will be taking, JOHN FULTON DI N JFD/rcw news about: Northfikld Laboratories Inc. TECHNOLOGY Researchers Step Up Efforts To Develop Synthetic Blood By FRANK E. JAMES Staff Reporter of Tmr WALL SIRE LIT JOURNAL 0 F THE FOUR MILLION AMERICANS who will receive "the gift of life" in the form of blood transfusions this year, more than 250,000 willet something more: hepatitis, a dan- gerous liver ailment. 6thers could contract an even worse malady: the virus that causes AIDS. Growing fears Of such complications among both doctors and patients have rekindled researchers' desire to make a safe synthetic lood. A b..,kd suistitute would have other ben- efits: It could prevent shortages of blood in medical emergencies, simplify transfusions by eliminating the need to match the blood type of I the recipient, and be made available to patients in ambulances and other places where storing fresh blood is impractical. Dozens of companies and universities are seeking a blood substitute, and one—Northfield Laboratories Inc., a small private research oliw2w4wl� concern near Chicago—is about to begin the first human clinical trials of a synthetic blood in several ears. Other companies could get clearance soon from the Food an Drug Administration to start human clinical trials, an agency official suggests. W NILE THE SEARCH for a synthetic blood is fraught with perils—for instance, allergic or immune reactions can be dangerous—competitors erous —competitors say Northfield's progress with its product, "polyhemoglobin," is significant. "It's an accom- plishment, and something that will set the ramework for others, in- cluding us," says Dale Smith, group vice president in char of blood products for Baxter Travenol Laboratories Inc., the big Feer - field, Ill. -based health-care products and services concern. ' The path to discovery in synthetic -blood research is strewn with casualties. Scientists so far have been stymied in their efforts to invent anything like hemoglobin, the unique compound in blood that enables it to perform the crucial oxygen -carrying function by absorbing and releasing oxygen. And past attempts to harness real hemoglobin have failed; ironically, pure hemoglobin is highly toxic to the kidneys. Polyhemoglobin is Northfield's only pproduct The firm's main researcher, Gerald Moss, who trained at the Met. ous Massachu- setts General Hospital, is a medical professor at tie University of Chica and head of surgery at Chicago's Michael Reese H ital. Dr. loo and has been investigating blood substitutes for near y 20 years. NIMAL STUDIES of polyhemoglobin have been successfully completed. But a human volunteer suffered a "mild allergic reaction" in a recent pilot test of polyhemoglobin, says Richard DeWoskin, Northfield's chairman. Researchers blame the patient: As a frequent plasma donor, the volunteer's blood was depleted of a protein that would have prevented the reaction, Mr. DeWoskin says. The FDA says it is aware of the incident, which Mr. DeWoskin calls "pretty innocuous." Human clinical trials are to start later this month. Northfield believes it has solved the problems that plagued other researchers. The Northfield substance, burgundy in color, uses real hemoglobin, as other substitutes have. But rather than using one hemoglobin molecule by itself, polyhemoglobin links two or .. ree to form a polymer --a repeating unit of the same structure. Northfield researchers belie this makes the substance nontoxic. They say it also increases polyhemoglobin's longevity within the vascular system tenfold to 40 hours. Northfield also claims it could safely use discarded blood to make polyhemoglobin because its manufacturing process kills vi- ruses. Glutaraldehyde, a cancer-causing chemical used to sterilize medical equipment, is used to form thepolyhemoglobin chains; dur- ing processing, it is washed out of the bblood substitute and doesn't pose a cancer risk, Northfield says. Because glutaraldehyde leaves the substance virus -free, the company says, tainted blood as well as clean blood could be used as a building block for polyhemoglobin. That could increase the raw materials available for manufacturing polyhemoglobin by more than two million pints of blood a year, Mr. DeWoskin estimates. UT SKEPTICS are raisingquestions about polyhemoglobin. Thomas F. Zuck, an FDA blood expert familiar with the Northfield product, says that while tests on baboons went well, "I sus t this product won't be any different than the others. No matter o we purify hemoglobin, we always end up with toxic issues that are difficult to solve." Even if human trials succeed, some researchers say North- field may have trouble making polyhemoglobin in large quantities. In the past, researchers at Northfield and elsewhere have lost con- trol of the molecular cross-linking process and created some un- wanted variations of the compound, says Harvey Klein, a transfu- sion expert with the U.S. Department of Health and Human Serv- ices. Also, supplies of discarded blood to use as a raw material may be negligible. ""A very small percentage, 1% to 396, of all 14 million units collected yearly are discarded," says Baxter's Mr. Smith. "It's not insignificant, but not nearly enough to make a major impact." Northfield researchers insist that their product is safe, promis- ing and worth the premium price the company would charge—$200 to $225 a pint, compared with $150 to $175 for blood. But if the com- pony fails, plenty of contenders are walting In the wings Baxter, Ab- bott Laboratories Inc., a Sun Co. substary named Adamantech Inc., Japanese and European concerns and university researchers all are trying to develop a blood substitute. news about Northfield Laboratoriies Inc, QU40 Tribut Friday, June 10, 1988 Artificial blood firm draws capital By David Elsner Northfield Laboratories Inc. of suburban Northfield received strong financial backing Thurs- day In its effort to develop the world's first artificial blood—a breakthrough that would end the danger of transmitting AIDS and hepatitis through transfusions rait'lu. 0, IC Industries Inc. paid $30 million for an 18at inter- est in Northfield, w "ich hopes to receive Food and Drug Adminis- tration approval to bring its hemo?obin product to market as early as late 1990, Several universities andnivatc companies, including gealth giant Baxter Laboratories Inc. and the much smaller Synthetic Blood Corp—both Chicago -arta firms—are known to be workin on blood substitutes. Northfiall says it is the most advanced, a claim that outside researchers fa- miliar with the company's prog- ress this week did not dispute, The FDA declined to comment. "I think we have about a two- year jump on the competition— and probably more like four," said Richard E. DeWoskin, Northfield's chairman. The development of nontoxic, oxygen -carrying blood substitu- tes has generated considerable interest In the medical and in vestment communities'primarily for their potential to elinliuste viral-discase, transmission a fear that already has caused many hospitals to cut back on transfusions, Last year approxi - ma= 4 million Americans re- ceiv blood transfusions, with more than 250,000 of them con- tracting hepatitis, a dangerous liver a=. 6A !;VZ1d86 of the as I have been attributed to t= finio the Centers for ���o Atlanta. But the benefits of artificial blood extend beyond disease-fift transfusions. Northfidd says its product is compatible withany blood type, thereby eliminating cross-matching risks and =C1 in, he variety of transfusion Quids a ho rttteatl has to k hand. No teld also 1=-si shelf life for its artificial blood of more than a year without freezing, compared with 28 to 42 days for whole blood, The Market for artificial blood appears enormous, with esti- mates of Potential worldwide Wes asas $I I billion a year. The ilii market for whole blood is about $1.8 billion a year, Northfield expects to sell its product for about $225 a pint, about 25 percent more than "red -cell" units and blood - volume expanders currently cost in the Chicago area, Northfield was founded in 1985 with venture-capital fund- ing of V million fitun Allstate Venture Capitit! in Northbrook and Mon M Medical Ven- ture Fun in cry Francisco, Citi later joined as an inves- tor, Industries' investment places the company's value cur- rently at $166 indlion. DeWoskin said* company would like to make public .blic stock offering t year aft" completing two more rounds of required human testing and building a production facility with the == IC, A firstsire was completed in liatr%= The results are excellent," DeWoskin said. "None of the (toxi- city) issues that stopped other hemoglobin red -0911 substitutes ,am up.. No chief rewaacher is Dr. Gerald Moss, a Navy sumstat dur- mg the Vietnam War and now it professor at the University, or ad. cap and had o(smWy at Michael prase Hospital. Moss has bow in- vestigating blood substitutes for nearly 20 years, initially under a contract with the Army to develop a substance that could be used on battlefield casualties, DeWoskin w stated Moss in that reaciuch. So far, scientists have been styrnied in efforts to create a blood substitute that can duplicate the crucial ox rid relcas- U* PMPctVtft7:O( =11:w Previ- ous versions have caused extensive liver i rpi v g k AV tevrthriTed's apparent Progress, "Them am still an enor. mous number of to over- oomit, . said Dc =. Zuck, a two or three took !1:14nr1;;:TPo1yMCr—A repe unit of the same structure Nofthfidd believes =I= the stance nontoxic. About 12 milhon pints of — each year in ft U.S. Of that, 10 miffim am with the rest discardod =�., 0011- tamination or because of having outlived their expiration datum. DeWoskin *ttrn-::"ixl that North- field could "capture" about $MAW that XMUSW 4011111titY as MW materurl and could sub - its stantial If discarded blood in Outstrips dmm& = lar 71.1.Ynaft- ukauring ;=. he s%gh any virus the original blood cells. theU S. -as - as the third . quay.. . ter W IM poilaps in Imew . markets before that, DeWoskin said, David Carter, Northfield's president, said the company was conservatively estimating sales of 3219 million seedIn I - fiscal -year, $45 mil, bon for its ending June 1, 1943. Several north sulburban sit= am under consideration for the com. 1='s production fitcility. North- er to break pound by Oct I, WO&W $94 For IC, thenis its first foray into the held of xrg** Although a tvum tMo1whle-UaMfth,� for as Karl Bans who forraieliv It— ti ow" Supply Corp. in Ev1MV-oft. her IC owns Pet I=, a food manu- facturer- Pepsi-Cola General ron" BgnkrN Au6;" Corp., a maker Well of refrigeration equipment, and ring Midair International,a car muffler hat retailer. It is in the proom of spin- sub- " oir its mwwA blood CONFIDENTIAL I. INTRODUCTION - EXECUTIVE SUMMARY Northfield Laboratories was founded in the late summer of 1985 to provide a corporate entity for commercializing the scientific developments of a research team specializing in hemoglobin -based blood substitutes who began their research effort in 1970. The mission statement of the company which was established at its founding remains its mission statement today. It reads: To complete development and profitably bring to the worldwide market an efficacious, safe hemoglobin based blood substitute that provides the oxygen carrying capacity of blood without the risk of disease (HIV, hepatitis, etc.) transmission. A' --r 18 years of research, Northfield Laboratories has become the c--ar leader in hemoglobin -based blood substitute technology. Having completed requisite research and animal testing, Northfield subAitted to the U.S. Food and Drug Administration an IND document in the fall of 1987. After thorough review by that regulatory body Northfield was released to begin testing its product in human volunteers in the summer of 1987. It is the only company involved in the human testing of a blood substitute. In March, 1988, Northfield successfully completed the first phase of human testing. The second phase is scheduled for the spring of 1989. Northfield estimates its competitive lead to be no less than two years and more like four years ahead of any worldwide competitor. The scientific effort over the years has been dedicated to producing a clinically useful product with the following areas of superiority to human blood: o Disease Free. Whole blood can transmit such viral diseases as HIV and hepatitis; parasitic diseases including malaria and trypanosomiasis; and, in some cases, bacterial infections. The production process for Northfield Laboratories' blood substitute (a process that would destroy blood) kills these disease organisms. o Univergal Compatibility. Typing and cross-matching are essential to safe transfusion of blood. Northfield's product is compatible with all blood types. This eliminates compatibility risks and reduces the variety of transfusion fluids a health facility must maintain. R CONFIDENTIAL ENtOU404 Shelf Life. While human blood has a useful life of 28-42 days, tests on the company's solution indicate a shelf life in excess of 12 months without freezing. Immediate Avail abilit . Because of its universal donor characteristics and long shelf life, the Northfield Laboratories product gives emergency care providers instant transfusion capability when time is most critical. Today, Northfield's research effort is housed at The Dreyfus Center of Michael Reese Hospital in Chicago. The research is being done in that facility under a research contract with Michael Reese Hospital, The principal investigator responsible for the scientific effort is Dr. Gerald Moss, who is Chairman of the Department of Surgery at Michael Reese Hospital and a Professor of Surgery at the University of Chicago. Dr. Moss has led the scientific effort since its inception in 1970. Over the years he has built the most highly respected group of scientists in the field Of hemoglobin research. The team is an inter -disciplinary group of five senior scientists (two clinicians, two biochemists and one biophysicist) supported by eight research associates. The most junior member of the senior scientific staff has been associated with the project for ten years. It is the combination of the interdisciplinary nature of the team and their length of time wrorking together on the project that has allowed Northfield to achieve its worldwide compe,.itiv-. lead. With the completion of human testing, scheduled for late 1990 and the anticipation of final issuance of a product license application from the U.S. Food and Drug Administration approximately one year later, Northfield plans to bring to the world market its polyhemoglobin product in early 1992. The worldwide market potential for a safe and effective substitute for the human red cell is estimated to be in excess of $10 billion. MINUTES COMMITTEE OF THE WHOLE AUGUST 22, 1989 I. ROLLCALL The meeting was called to order at 7:32 p.m. Present at the meeting were: Mayor Gerald L Farley; Trustees Ralph Arthur, Mark Busse, Timothy Corcoran, Leo Floros, George Van Geem and Theodore Wattenberg. Also present at the meeting were: Village Manager John Fulton Dixon, Assistant Village Ma ger Michael Janonis, Fire Chief Edward Cavello, Police Chief Ronald Pavlock, Finance Director 'David Jepson, Public Works Director Herbert Weeks, Deputy Police Chief Ronald Richardson, Police Commander Joseph Kolanowski and Deputy Fire Chiefs Lonnie Jackson and Del Ulreich. Also present were three persons from the print media. 11. MINUTE The Minutes of the Committee of the Whole meeting of August 8, 1989 were accepted and filed. III. -CN 3TIZF, S TO BE HEAR Mr. Don Harmon, 16 North William, appeared before Committee members to request a meeting between the Village, Mount Prospect Park District officials, representatives of the Creative Children's Academy and 'residents living near the old Busse School site. Mr. Harmon was protesting the anticipated installation of a mobile classroom at the site in order to facilitate expansion of the Creative Children's Academy program. Mr. Harmon felt that this expansion required the Academy of obtain a Special Use Permit prior to installation of the trailer. Mayor Farley directed the staff to set up a meeting with the Park District within the next two weeks to discuss this matter with area residents. Committee members recognized the birthdays of Trustee Leo Floros, and Trustee Ralph Arthur. IV. P-UBLI!Q SAEM EACILITy gEpQ Assistant Village Manager Michael Janonis briefly reviewed with Committee members the contents of the Public Safety Committee Report and indicated that Committee members were present in order to answer questions. General discussion among Committee members was generally favorable to staff recommendation of retaining a consultant to do a Space Utilization Study for the Public Safety Facility. It was made clear by the "Village Manager that this was a first step and slid not commit the Mayor and Board of Trustees to further action. However, in order to fully explore the range of options available, it was necessary to retain a third party professional, with expertise in designing such facilities. Trustee Ralph Arthur stated his overall approval of the Committee report and indicated that he anticipated an upgraded facility would be possible at the same location using the same facade of the existing building. Trustee Marla Busse indicated that the report was well. detailed. Further, he stated that the Police and Fire services were very important to all citizens within the Village and that the deficiencies identified in the report needed to be addressed. Trustee George Van Geem indicated that he would like information on whw the cost would be if the Village did no substantial renovation, Included in that would be the cost of inefficiencies caused by the existing facility.,, Trustee Timothy Corcoran indicated that the report was well constructed and he generally accepted the staff recommendation to retain a consultant. However, he was concerned that the firm of Donohue and Associates did not appear to have extensive background in designing ,Police and Fire facilities. Trustee Corcoran indicated that the second low bid of OWP&P appeared to have more experience in this type of project.' Village Manager John Fulton Dixon. responded that his past experience with OWP&P had not proved to be satisfactory and that the Village's working relationship with Donohue and Associates as well as their experience in the design of Police and Fire facilities was sufficient to warrant the Committee's recommendation. Fred Borich, Vice President' of Donohue and Associates, indicated that his firm had extensive experience in designing Police and Fire facilities. Trustee Ted Wattenberg indicated his support for the report. Trustee Leo Floros also indicated that he supported the recommendation to retain Donohue and Associates. Finance Director David Jepson reviewed with Committee members his initial memorandum regarding financing for a new Public Safety Facility. Mr. Jepson indicated that overall, the Village was in very good financial condition and could support a $4 million Bond Issue should a. new facility be constructed. -2- Additional discussion among Committee members resulted in a consensus that the recommendation of the staff to retain the firm of Donohue and Associates to conduct a Space Utilization Study for an amount not to exceed $15,900 be adopted. This item will be before the Board at the September 5 Board meeting for official ratification. V. ELLAGE MANAGER'S REPO Mr. Dixon reported that progress on the upgrading of Melas Park was continuing. Discussions between the Arlington Heights and Mount Prospect Park Districts have not quite concluded with regard to the final configuration of the ball fields at the site. Mr. Dixon said he would report back when this matter had been resolved. VI. ANY OTHER BUSINESS Trustee Ted Wattenberg indicated that the Village Board should monitor clo< the legal bills of the Solid Waste Agency of Northern Cook County. Trustee Wattenberg indicated that litigation between two government bodies; i.e. SWANCC and Bartlett, should be avoided if possible, Trustee Ralph Arthur indicated that the efforts of the Solid Waste Agency of Northern Cook County were the best hope for the northwest suburbs in dealing with the landfill crisis. He indicated that the legal bills were scrutinized by the Executive Cr irnitV ,! on a regular basis and he felt that the expenditures were prudent under the -ircumstances. V11. ADJOURNMENT There being no further business before the Committee of the Whole, the meetir, was adjourned at 8:32 p.m. MEJ/rcw Respectfully submitted, MICHAEL E. JANONIS Assistant Village Manager -3- Mr. John Fulton Dixon Village Manager Village of Mt. Prospect 100 S. Emerson Mt. Prospect, Il. 60056 July 26, 1989 Dear Mr. Dixon: We, the neighbors in the Barberry, Juniper area have reestablished our committee of homeowners to fight, what we feel is the unjust and frankly, discriminatory application of village rules, policies and ordinances by the Public Works Department and other village departments. You have received letters from others in our group who have similar feelings and grievances about these issues and the heavy handed approach of the v1llase, We are not sure that these departments have the best interest ~ the homeowners in mind because we have attempted to compromise with these departments (especially guuIio Works) but were told that they would not compromise and only the Village Board can effect a compromise. We respectfully request the opportunity to bring these issues before the village board. We are positive that these departments can not be fulfilling the wishes of the village board because the village board has repeatedly demonstrated good judgement and common sense. We would appreciate the opportunity to bear the board's point of view and let our feelings be buono. As we are unable to attend the August meeting, may we be placed on the agenda for the September 5, 1989 board meeting? We also respectfully request that no action by village departments be taken against os prior to our meeting with the village board. We would be happy to discuss any of these matters with you prior to the September meeting and remain entirely at your disposal. We thank you in advance for your kind attention in this matter. Very truly 'Sph,n B. �Alpert 1121 Barberry Lane 8t. Prospect, Il. 60056 oo. Mayor Farley Herbert Weeks nirector Herbert L. Weeks Deputy Director Glen R. Andler Water Superintendent Jerry W McIntosh Street Superintendent Melvyn L. Both Forestry Superintendent Sandra M. Clark Ad.jni.t,.ti­ Aid. M. Lisa Angell Mount Prospect Public Works Department 1700 W. Central Road, Mount Prospect, Illinois 60056 TRu cny ISA Rhone 312/B70-5840 July 27, 1989 Mr. & Mrs. William J. Armocida 1118 Barberry Lane Mount Prospect, IL 60056 Dear Mr. & Mrs. Armocida: Your letter of July 23, 1989, was passed on to me for review." In your letter you have requested that the stop sign recently installed in front of your residence be moved 141 further east. You also indicated that there was a commitment that the sign would be placed according to a map which you were given. I have had our Traffic Engineer and Street Superintendent review the placement and have observed it personally. The map used as an exhibit specifically states that the placement of the stop sign would be 331 west of your neighbor's driveway on the east side of your residence. Our man in the sign division actually placed the sign at 321 which is 11 further east than the drawing indicated. Our Traffic Engineer has stated that placement of the sign meets the standards established by the Illinois Department of Transpor- tation's Manual on Traffic Devices. To move it 141 east would not be conforming to that manual's guidelines. The red mark on the curb was placed by our Sign Division only as a guide for other underground utility companies to locate their facilities so that when a post is driven into the ground nothing else would be damaged. I am sorry for the misunderstanding on your part, but I have attached a copy of the drawing that our personnel worked with. Sincerely, HLW/eh cc: Village Manager Dixon V*' Traffic Engineer Johanson Attachment n�i-r!g tJGD STAL-L—A:-r � 7-1 cc STOP SIGN {} 33' .STQ SIGN,- B` • USHE MUST BE KEEN ° RIMMED 0. AS TO NOT OSS UCT SIGH-. t FIRE HY ANT S OP .SIGN fi ` G TR E MAY HA `} E I ED IN FUTURE AS O T 013STRUCT SIG �'� Y. Rel 8127,88 SIGHT OBSTRUCTION LIST July 28, 1989 L. Schrambeck 1750 Azalea Place Three pines, 121 - 201 Thomas Van Puynbrouch 1756 Azalea Place one 121 pine David Fontanetta 1760 Azalea Place One 81 pine James B. Hubert 1817 Basswood Two 251 spruce Theo Voelkner 931 Quince One 31 juniper Malcolm Holec 927 Quince 31 juniper clump Howard A. Washer 913 Quince One 61 Russian olive shrub Lawrence Horwitz 1828 Bittersweet One 31 juniper Joseph Saladin 1802 Bittersweet Two spruce trees, 81 and 181 J. Krzestnski 1006 Burning Bush Two 3' barberry hedges Edward Nowak 1806 Apache Two 41 junipers Robert Gresens 1010 Moki Two 121 spruce Frank Bocian 927 Pecos One 221 spruce George Mitchell 901 Sumac Two 81 pines P. O'Toole 903 Sumac One 61 shrub Gerald Gregory 1905 Cholo One 3-1/21 shrub Richard Merkel 1908 Cholo One 101 spruce